The hallucinogen d-lysergic acid diethylamide (d-LSD) induces the immediate-early gene c-Fos in rat forebrain

Paul S. Frankel, Kathryn Cunningham

Research output: Contribution to journalArticle

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Abstract

The hallucinogen d-lysergic acid diethylamide (d-LSD) evokes dramatic somatic and psychological effects. In order to analyze the neural activation induced by this unique psychoactive drug, we tested the hypothesis that expression of the immediate-early gene product c-Fos is induced in specific regions of the rat forebrain by a relatively low, behaviorally active, dose of d-LSD (0.16 mg/kg, i.p.); c-Fos protein expression was assessed at 30 min, and 1, 2 and 4 h following d-LSD injection. A time- and region-dependent expression of c-Fos was observed with a significant increase (P<0.05) in the number of c-Fos-positive cells detected in the anterior cingulate cortex at 1 h, the shell of the nucleus accumbens at 1 and 2 h, the bed nucleus of stria terminalis lateral at 2 h and the paraventricular hypothalamic nucleus at 1, 2 and 4 h following systemic d-LSD administration. These data demonstrate a unique pattern of c-Fos expression in the rat forebrain following a relatively low dose of d-LSD and suggest that activation of these forebrain regions contributes to the unique behavioral effects of d-LSD.

LanguageEnglish (US)
Pages251-260
Number of pages10
JournalBrain Research
Volume958
Issue number2
DOIs
StatePublished - Dec 27 2002

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Hallucinogens
Lysergic Acid Diethylamide
Immediate-Early Genes
Prosencephalon
Proto-Oncogene Proteins c-fos
Activation Analysis
Septal Nuclei
Paraventricular Hypothalamic Nucleus
Psychotropic Drugs
Gyrus Cinguli
Nucleus Accumbens
Psychology
Injections

Keywords

  • c-Fos
  • Forebrain
  • Hallucinogen

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The hallucinogen d-lysergic acid diethylamide (d-LSD) induces the immediate-early gene c-Fos in rat forebrain. / Frankel, Paul S.; Cunningham, Kathryn.

In: Brain Research, Vol. 958, No. 2, 27.12.2002, p. 251-260.

Research output: Contribution to journalArticle

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