Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Dora Abraham, Janos Feher, Gian Luca Scuderi, Dora Szabo, Arpad Dobolyi, Melinda Cservenak, Janos Juhasz, Balazs Ligeti, Sandor Pongor, Mari Carmen Gomez-Cabrera, Jose Vina, Mitsuru Higuchi, Katsuhiro Suzuki, Istvan Boldogh, Zsolt Radak

Research output: Contribution to journalArticle

Abstract

It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1TG). APP/PS1TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p < 0.05), and this group of bacteria was significantly elevated in the microbiome of the APP/PS1TG mice compared to the wild type. L. johnsonii levels positively correlated with the beta amyloid content and area. Data revealed that exercise and probiotic treatment can decrease the progress of Alzheimer's Disease and the beneficial effects could be partly mediated by alteration of the microbiome.

Original languageEnglish (US)
Pages (from-to)122-131
Number of pages10
JournalExperimental Gerontology
Volume115
DOIs
StatePublished - Jan 1 2019

Fingerprint

Microbiota
Probiotics
Transgenic Mice
Alzheimer Disease
Amyloid
Exercise
Amyloid Plaques
Deterioration
Hippocampus
Bacteria
Biomarkers

Keywords

  • Alzheimer
  • Exercise
  • Microbiome
  • Probiotics

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

Cite this

Abraham, D., Feher, J., Scuderi, G. L., Szabo, D., Dobolyi, A., Cservenak, M., ... Radak, Z. (2019). Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome. Experimental Gerontology, 115, 122-131. https://doi.org/10.1016/j.exger.2018.12.005

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice : Role of microbiome. / Abraham, Dora; Feher, Janos; Scuderi, Gian Luca; Szabo, Dora; Dobolyi, Arpad; Cservenak, Melinda; Juhasz, Janos; Ligeti, Balazs; Pongor, Sandor; Gomez-Cabrera, Mari Carmen; Vina, Jose; Higuchi, Mitsuru; Suzuki, Katsuhiro; Boldogh, Istvan; Radak, Zsolt.

In: Experimental Gerontology, Vol. 115, 01.01.2019, p. 122-131.

Research output: Contribution to journalArticle

Abraham, D, Feher, J, Scuderi, GL, Szabo, D, Dobolyi, A, Cservenak, M, Juhasz, J, Ligeti, B, Pongor, S, Gomez-Cabrera, MC, Vina, J, Higuchi, M, Suzuki, K, Boldogh, I & Radak, Z 2019, 'Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome' Experimental Gerontology, vol. 115, pp. 122-131. https://doi.org/10.1016/j.exger.2018.12.005
Abraham, Dora ; Feher, Janos ; Scuderi, Gian Luca ; Szabo, Dora ; Dobolyi, Arpad ; Cservenak, Melinda ; Juhasz, Janos ; Ligeti, Balazs ; Pongor, Sandor ; Gomez-Cabrera, Mari Carmen ; Vina, Jose ; Higuchi, Mitsuru ; Suzuki, Katsuhiro ; Boldogh, Istvan ; Radak, Zsolt. / Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice : Role of microbiome. In: Experimental Gerontology. 2019 ; Vol. 115. pp. 122-131.
@article{eac386539efc4bf39b161c952a1c2695,
title = "Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome",
abstract = "It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1TG). APP/PS1TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p < 0.05), and this group of bacteria was significantly elevated in the microbiome of the APP/PS1TG mice compared to the wild type. L. johnsonii levels positively correlated with the beta amyloid content and area. Data revealed that exercise and probiotic treatment can decrease the progress of Alzheimer's Disease and the beneficial effects could be partly mediated by alteration of the microbiome.",
keywords = "Alzheimer, Exercise, Microbiome, Probiotics",
author = "Dora Abraham and Janos Feher and Scuderi, {Gian Luca} and Dora Szabo and Arpad Dobolyi and Melinda Cservenak and Janos Juhasz and Balazs Ligeti and Sandor Pongor and Gomez-Cabrera, {Mari Carmen} and Jose Vina and Mitsuru Higuchi and Katsuhiro Suzuki and Istvan Boldogh and Zsolt Radak",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.exger.2018.12.005",
language = "English (US)",
volume = "115",
pages = "122--131",
journal = "Experimental Gerontology",
issn = "0531-5565",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice

T2 - Role of microbiome

AU - Abraham, Dora

AU - Feher, Janos

AU - Scuderi, Gian Luca

AU - Szabo, Dora

AU - Dobolyi, Arpad

AU - Cservenak, Melinda

AU - Juhasz, Janos

AU - Ligeti, Balazs

AU - Pongor, Sandor

AU - Gomez-Cabrera, Mari Carmen

AU - Vina, Jose

AU - Higuchi, Mitsuru

AU - Suzuki, Katsuhiro

AU - Boldogh, Istvan

AU - Radak, Zsolt

PY - 2019/1/1

Y1 - 2019/1/1

N2 - It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1TG). APP/PS1TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p < 0.05), and this group of bacteria was significantly elevated in the microbiome of the APP/PS1TG mice compared to the wild type. L. johnsonii levels positively correlated with the beta amyloid content and area. Data revealed that exercise and probiotic treatment can decrease the progress of Alzheimer's Disease and the beneficial effects could be partly mediated by alteration of the microbiome.

AB - It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1TG). APP/PS1TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p < 0.05), and this group of bacteria was significantly elevated in the microbiome of the APP/PS1TG mice compared to the wild type. L. johnsonii levels positively correlated with the beta amyloid content and area. Data revealed that exercise and probiotic treatment can decrease the progress of Alzheimer's Disease and the beneficial effects could be partly mediated by alteration of the microbiome.

KW - Alzheimer

KW - Exercise

KW - Microbiome

KW - Probiotics

UR - http://www.scopus.com/inward/record.url?scp=85058156527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058156527&partnerID=8YFLogxK

U2 - 10.1016/j.exger.2018.12.005

DO - 10.1016/j.exger.2018.12.005

M3 - Article

VL - 115

SP - 122

EP - 131

JO - Experimental Gerontology

JF - Experimental Gerontology

SN - 0531-5565

ER -