Xiaoyong Bao

PhD

  • 1038 Citations
  • 19 h-Index
19972020
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Personal profile

Personal profile

Dr. Bao is an Associate Professor of Pediatrics in the Division of Clinic and Experimental Immunology and Infectious Disease. She received her PhD in the Cellular Physiology and Molecular Biophysics from the University of Texas Medical Branch in Galveston. Dr. Bao continued her education as a J.Kempner scholar for the year 2003-2004 and completed her postdoctoral fellowship in a NIAID-supported T32 training program for emerging and reemerging infectious in UTMB. One of her research interests focuses on biological roles of small non-coding RNAs (sncRNAs), especially the newly discovered sncRNA derived from tRNA, in response to viral infection and environmental stimuli. Biological function studies of sncRNAs are a burgeoning field of interdisciplinary research that crosses the path from chemistry, molecular biology, bioinformatics and computer sciences. The ultimate goal of her sncRNA research is to control viral replication or stress-induced cellular responses by regulating the expression of sncRNAs. Her other research interests include identifying the mechanisms associated with immune evasion of respiratory syncytial virus (RSV) and human metapneumovirus (hMPV), the two leading causes of lower respiratory tract infection in children, and developing therapeutic molecules and attenuated vaccine candidates to combat or prevent these two viral infections.

Research interests

The research in my lab focuses on molecular mechanisms underlying the pathogenesis and host immune responses associated with RSV and hMPV infections, the two leading causes of lower respiratory tract infections in infants. We aim to identify antiviral pathways, viral evasion mechanisms, and roles of sncRNAs in RSV/hMPV infection. The ultimate goal of our research is to develop effective preventive and therapeutic strategies against respiratory virus-associated viral replication and inflammation.

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Projects 2012 2020

Research Output 1997 2018

  • 1038 Citations
  • 19 h-Index
  • 37 Article
  • 1 Chapter

Exchange Proteins Directly Activated by cAMP and Their Roles in Respiratory Syncytial Virus Infection

Choi, E. J., Ren, Y., Chen, Y., Liu, S., Wu, W., Ren, J., Wang, P., Garofalo, R., Zhou, J. & Bao, X., Nov 15 2018, In : Journal of virology. 92, 22

Research output: Contribution to journalArticle

Respiratory Syncytial Virus Infections
Respiratory Syncytial Viruses
viruses
virus replication
infection
1 Citations

Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells

Bao, X., Kolli, D., Esham, D., Velayutham, T. S. & Casola, A., Jun 1 2018, In : Viruses. 10, 6, 278.

Research output: Contribution to journalArticle

Metapneumovirus
Dendritic Cells
Interferons
TNF Receptor-Associated Factor 6
Interferon Type I
1 Citations

Detection of nuclear protein profile changes by human metapneumovirus M2-2 protein using quantitative differential proteomics

Ren, Y., Choi, E., Zhang, K., Chen, Y., Ye, S., Deng, X., Zhang, K. & Bao, X., Dec 1 2017, In : Vaccines. 5, 4, 45.

Research output: Contribution to journalArticle

Metapneumovirus
Nuclear Proteins
Proteomics
PDZ Domains
Proteome
8 Citations

Identification of two novel functional tRNA-derived fragments induced in response to respiratory syncytial virus infection

Zhou, J., Liu, S., Chen, Y., Fu, Y., Silver, A. J., Hill, M. S., Lee, I., Lee, Y. S. & Bao, X., Jul 1 2017, In : Journal of General Virology. 98, 7, p. 1600-1610 11 p., 000852.

Research output: Contribution to journalArticle

Respiratory Syncytial Virus Infections
Transfer RNA
Respiratory Syncytial Viruses
RNA
Virus Replication
9 Citations

Functional motifs responsible for human metapneumovirus M2-2-mediated innate immune evasion

Chen, Y., Deng, X., Deng, J., Zhou, J., Ren, Y., Liu, S., Prusak, D. J., Wood, T. & Bao, X., Dec 1 2016, In : Virology. 499, p. 361-368 8 p.

Research output: Contribution to journalArticle

Metapneumovirus
Immune Evasion
Antiviral Agents
Proteins
TNF Receptor-Associated Factor 5