Projects per year
Personal profile
Personal profile
Dr. Bao is an Associate Professor of Pediatrics in the Division of Clinic and Experimental Immunology and Infectious Disease. She received her PhD in the Cellular Physiology and Molecular Biophysics from the University of Texas Medical Branch in Galveston. Dr. Bao continued her education as a J.Kempner scholar for the year 2003-2004 and completed her postdoctoral fellowship in a NIAID-supported T32 training program for emerging and reemerging infectious in UTMB. One of her research interests focuses on biological roles of small non-coding RNAs (sncRNAs), especially the newly discovered sncRNA derived from tRNA, in response to viral infection and environmental stimuli. Biological function studies of sncRNAs are a burgeoning field of interdisciplinary research that crosses the path from chemistry, molecular biology, bioinformatics and computer sciences. The ultimate goal of her sncRNA research is to control viral replication or stress-induced cellular responses by regulating the expression of sncRNAs. Her other research interests include identifying the mechanisms associated with immune evasion of respiratory syncytial virus (RSV) and human metapneumovirus (hMPV), the two leading causes of lower respiratory tract infection in children, and developing therapeutic molecules and attenuated vaccine candidates to combat or prevent these two viral infections.
Research interests
The research in my lab focuses on molecular mechanisms underlying the pathogenesis and host immune responses associated with RSV and hMPV infections, the two leading causes of lower respiratory tract infections in infants. We aim to identify antiviral pathways, viral evasion mechanisms, and roles of sncRNAs in RSV/hMPV infection. The ultimate goal of our research is to develop effective preventive and therapeutic strategies against respiratory virus-associated viral replication and inflammation.
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Projects 2012 2020
Exchange Proteins Directly Activated by cAMP, a Novel Protein Contributing to Virus-induced Sinusitis
7/1/17 → 6/30/20
Project: Other project
Role of tRNA-derived RNA Fragments (tRFs) in Respiratory Syncytia Virus (RSV) Infection
National Inst of Allergy & Infectious Di
12/1/15 → 11/30/20
Project: Other project › Research
EL II: Functional Portraits of tRNA-derived Small Non-coding RNAs
National Inst of Allergy & Infectious Di
6/15/15 → 5/31/17
Project: Other project › Research
Respiratory Syncytial Virus Utilizes a tRNA 5'-end Fragment to Suppress Host antiviral Response
11/30/14 → 11/29/16
Project: Other project › Research
EL II: Characterization of tRNA-derived RNA Fragments (tRFs) in Respiratory Syncytial Virus Infection
National Inst of Allergy & Infectious Di
4/1/14 → 3/31/16
Project: Other project › Research
Research Output 1997 2018
A tRNA-derived RNA Fragment Plays an Important Role in the Mechanism of Arsenite -induced Cellular Responses
Liu, S., Chen, Y., Ren, Y., Zhou, J., Ren, J., Lee, I. & Bao, X., Dec 1 2018, In : Scientific reports. 8, 1, 16838.Research output: Contribution to journal › Article
Exchange Proteins Directly Activated by cAMP and Their Roles in Respiratory Syncytial Virus Infection
Choi, E-J., Ren, Y., Chen, Y., Liu, S., Wu, W., Ren, J., Wang, P., Garofalo, R., Zhou, J. & Bao, X., Nov 15 2018, In : Journal of virology. 92, 22Research output: Contribution to journal › Article
Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells
Bao, X., Kolli, D., Esham, D., Velayutham, T. S. & Casola, A., Jun 1 2018, In : Viruses. 10, 6, 278.Research output: Contribution to journal › Article
Detection of nuclear protein profile changes by human metapneumovirus M2-2 protein using quantitative differential proteomics
Ren, Y., Choi, E-J., Zhang, K., Chen, Y., Ye, S., Deng, X., Zhang, K. & Bao, X., Dec 1 2017, In : Vaccines. 5, 4, 45.Research output: Contribution to journal › Article
Identification of two novel functional tRNA-derived fragments induced in response to respiratory syncytial virus infection
Zhou, J., Liu, S., Chen, Y., Fu, Y., Silver, A. J., Hill, M. S., Lee, I., Lee, Y. S. & Bao, X., Jul 1 2017, In : Journal of General Virology. 98, 7, p. 1600-1610 11 p., 000852.Research output: Contribution to journal › Article