• 1933 Citations
  • 27 h-Index
1992 …2019
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Personal profile

Personal profile

Member, Institute for Human Infections & Immunity

Personal profile

Division: Vaccinology

Dr. Pyles in a Professor in the Department of Pediatrics and Microbiology & Immunology and co-Director of the UTMB Assay Development Services Division in the Galveston National Lab. He received his B.A. in Biology and Chemistry from Hanover College, Indiana. He received his PhD in Molecular Genetics and Biochemistry & Microbiology from the University of Cincinnati College of Medicine. He completed his postdoctoral fellowship in the Department of Cell Biology, Neurobiology and Anatomy at the University of Cincinnati.  He joined UTMB in 2000 as part of the establishment of the Sealy Center for Vaccine Development.

Dr. Pyles’ research interests focus on the interaction of host mucosae with the bacterial communities (microbiome) and pathogens that dramatically impact human health.  His career has been primarily focused on improving women’s health including study of sexually-transmitted infections. He is currently involved in preclinical and clinical studies of devices and interventions that increase ease of use and efficacy of next generation therapies.  Recent work has led to the establishment of novel systems to study both vaginal and nasal human mucosae after colonization by transplanted microbiome communities.

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  • 2 Similar Profiles
Human Herpesvirus 2 Medicine & Life Sciences
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Herpes Genitalis Medicine & Life Sciences
Guinea Pigs Medicine & Life Sciences
Respiratory Tract Infections Medicine & Life Sciences
Viruses Medicine & Life Sciences
Mycoplasma genitalium Medicine & Life Sciences
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Projects 2014 2019

Research Output 1992 2019

  • 1933 Citations
  • 27 h-Index
  • 67 Article

Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2

Bourne, N., Banasik, B. N., Perry, C. L., Miller, A. L., White, M., Pyles, R. & Milligan, G., Jan 2 2019, In : Virology. 526, p. 180-188 9 p.

Research output: Contribution to journalArticle

Human Herpesvirus 2
Virus Shedding
1 Citations

Phase I trial of pod-intravaginal rings delivering antiretroviral agents for HIV-1 prevention: Rectal drug exposure from vaginal dosing with tenofovir disoproxil fumarate, emtricitabine, and maraviroc

Vincent, K., Moss, J. A., Marzinke, M. A., Hendrix, C. W., Anton, P. A., Gunawardana, M., Dawson, L. N., Olive, T. J., Pyles, R. & Baum, M. M., Aug 1 2018, In : PLoS ONE. 13, 8, e0201952.

Research output: Contribution to journalArticle

Anti-Retroviral Agents
Human immunodeficiency virus 1

Safety and pharmacokinetics of single, dual, and triple antiretroviral drug formulations delivered by pod-intravaginal rings designed for HIV-1 prevention: A Phase I trial

Vincent, K., Moss, J. A., Marzinke, M. A., Hendrix, C. W., Anton, P. A., Pyles, R., Guthrie, K. M., Dawson, L., Olive, T. J., Butkyavichene, I., Churchman, S. A., Cortez, J. M., Fanter, R., Gunawardana, M., Miller, C. S., Yang, F., Rosen, R. K., Vargas, S. E. & Baum, M. M., Sep 1 2018, In : PLoS Medicine. 15, 9, e1002655.

Research output: Contribution to journalArticle

Drug Compounding
Dengue Virus
Dengue Vaccines
Interferon Receptors

Transcriptional Analysis of the Guinea Pig Mucosal Immune Response to Intravaginal Infection with Herpes Simplex Virus Type 2

Veselenak, R. L., Milligan, G., Miller, A. L., Pyles, R. & Bourne, N., May 1 2018, In : Virology. 518, p. 349-357 9 p.

Research output: Contribution to journalArticle

Mucosal Immunity
Human Herpesvirus 2
Guinea Pigs