Projects per year
Personal profile
Personal profile
Member, Institute for Human Infections & Immunity
Personal profile
Division: Vaccinology
Dr. Bourne is a Professor in the Department of Pediatrics and Senior Scientist with the Sealy Center for Vaccine Development. He received his PhD from the University of Wales (Cardiff) Institute of Science and Technology. His research focus for over twenty years has been the development and evaluation of novel vaccines and therapeutics against viral infections with an emphasis on in vivo studies in appropriate small animal models. One of the principal areas of interest has been the development, refinement and use of mouse and guinea pig models of genital herpes disease to explore the impact of novel vaccines, antiviral agents and topical microbicides. In addition, for the past ten years he has worked extensively with small animal models of flavivirus diseases, in particular West Nile encephalitis, Japanese encephalitis and Dengue.
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Human Herpesvirus 2
Medicine & Life Sciences
Herpes Genitalis
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Guinea Pigs
Medicine & Life Sciences
Virus Diseases
Medicine & Life Sciences
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Infection
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Vaccines
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Viruses
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Network
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Projects 2006 2018
- 10 Completed
Preclinical development of a tenofovir intravaginal ring for HIV prophylaxis
5/1/14 → 6/30/15
Project: Other project
Research Output 1992 2019
Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2
Bourne, N., Banasik, B. N., Perry, C. L., Miller, A. L., White, M., Pyles, R. & Milligan, G., Jan 2 2019, In : Virology. 526, p. 180-188 9 p.Research output: Contribution to journal › Article
Human Herpesvirus 2
Virus Shedding
Foreskin
Perineum
Immunity
Increased frequency of virus shedding by herpes simplex virus 2-infected Guinea pigs in the absence of CD4 T lymphocytes
Bourne, N., Perry, C. L., Banasik, B. N., Miller, A. L., White, M., Pyles, R., Schäfer, H. & Milligan, G., Feb 1 2019, In : Journal of Virology. 93, 4, e0172118.Research output: Contribution to journal › Article
Human herpesvirus 2
Virus Shedding
viral shedding
Human Herpesvirus 2
guinea pigs
3
Citations
(Scopus)
Characterization of a murine model of non-lethal, symptomatic dengue virus infection
Sarathy, V., White, M., Li, L., Kaiser, J. A., Campbell, G., Milligan, G., Bourne, N. & Barrett, A., Dec 1 2018, In : Scientific Reports. 8, 1, 4900.Research output: Contribution to journal › Article
Dengue Virus
Virus Diseases
Infection
Dengue
Severe Dengue
Spectrum of activity testing for therapeutics against all four dengue virus serotypes in AG129 mouse models: Proof-of-concept studies with the adenosine nucleoside inhibitor NITD-008
Milligan, G., White, M., Zavala, D., Pyles, R., Sarathy, V., Barrett, A. & Bourne, N., Jun 1 2018, In : Antiviral Research. 154, p. 104-109 6 p.Research output: Contribution to journal › Article
Dengue Virus
Nucleosides
Adenosine
Dengue Vaccines
Interferon Receptors
1
Citation
(Scopus)
Transcriptional Analysis of the Guinea Pig Mucosal Immune Response to Intravaginal Infection with Herpes Simplex Virus Type 2
Veselenak, R. L., Milligan, G., Miller, A. L., Pyles, R. & Bourne, N., May 1 2018, In : Virology. 518, p. 349-357 9 p.Research output: Contribution to journal › Article
Mucosal Immunity
Human Herpesvirus 2
Guinea Pigs
Infection
Immunity