• 3286 Citations
  • 33 h-Index
1992 …2019
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Personal profile

Personal profile

Member, Institute for Human Infections & Immunity

Personal profile

Division: Vaccinology

Dr. Bourne is a Professor in the Department of Pediatrics and Senior Scientist with the Sealy Center for Vaccine Development. He received his PhD from the University of Wales (Cardiff) Institute of Science and Technology. His research focus for over twenty years has been the development and evaluation of novel vaccines and therapeutics against viral infections with an emphasis on in vivo studies in appropriate small animal models. One of the principal areas of interest has been the development, refinement and use of mouse and guinea pig models of genital herpes disease to explore the impact of novel vaccines, antiviral agents and topical microbicides. In addition, for the past ten years he has worked extensively with small animal models of flavivirus diseases, in particular West Nile encephalitis, Japanese encephalitis and Dengue.

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Human Herpesvirus 2 Medicine & Life Sciences
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Vaccines Medicine & Life Sciences
Viruses Medicine & Life Sciences

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Projects 2006 2018

Research Output 1992 2019

  • 3286 Citations
  • 33 h-Index
  • 98 Article
  • 2 Chapter

Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2

Bourne, N., Banasik, B. N., Perry, C. L., Miller, A. L., White, M., Pyles, R. & Milligan, G., Jan 2 2019, In : Virology. 526, p. 180-188 9 p.

Research output: Contribution to journalArticle

Foreskin
Perineum
Human Herpesvirus 2
Virus Shedding
Immunity

Characterization of a murine model of non-lethal, symptomatic dengue virus infection

Sarathy, V., White, M., Li, L., Kaiser, J. A., Campbell, G., Milligan, G., Bourne, N. & Barrett, A., Dec 1 2018, In : Scientific Reports. 8, 1, 4900.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Infection
Dengue
Severe Dengue
Dengue Virus
Nucleosides
Adenosine
Dengue Vaccines
Interferon Receptors

Transcriptional Analysis of the Guinea Pig Mucosal Immune Response to Intravaginal Infection with Herpes Simplex Virus Type 2

Veselenak, R. L., Milligan, G., Miller, A. L., Pyles, R. & Bourne, N., May 1 2018, In : Virology. 518, p. 349-357 9 p.

Research output: Contribution to journalArticle

Mucosal Immunity
Human Herpesvirus 2
Guinea Pigs
Infection
Immunity
2 Citations

A lethal model of disseminated dengue virus type 1 infection in AG129 mice

Milligan, G., Sarathy, V., White, M. M., Greenberg, M. B., Campbell, G., Pyles, R., Barrett, A. & Bourne, N., Oct 1 2017, In : Journal of General Virology. 98, 10, p. 2507-2519 13 p., 000923.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Dengue
Antibody-Dependent Enhancement
Vaccines