• 2542 Citations
  • 30 h-Index
1994 …2023
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  • 2 Similar Profiles
Glutamate Carboxypeptidase II Medicine & Life Sciences
Derivatives Chemical Compounds
Neoplasms Medicine & Life Sciences
Protease Inhibitors Medicine & Life Sciences
Proteins Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Pharmacology Medicine & Life Sciences
Oxides Chemical Compounds

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Projects 2012 2023

Research Output 1994 2019

Antifibrosis effect of novel oridonin analog CYD0618 via suppression of the NF-κB pathway

Cummins, C. B., Wang, X., Xu, J., Hughes, B. D., Ding, Y., Chen, H., Zhou, J. & Radhakrishnan, R., Dec 1 2018, In : Journal of Surgical Research. 232, p. 283-292 10 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Lipopolysaccharides
Apoptosis
Phosphorylation
Cell Proliferation
2 Citations

Discovery of novel mifepristone derivatives via suppressing KLF5 expression for the treatment of triple-negative breast cancer

Lin, Y., Liu, R., Zhao, P., Ye, J., Zheng, Z., Huang, J., Zhang, Y., Gao, Y., Chen, H., Liu, S., Zhou, J., Chen, C. & Chen, H., Feb 25 2018, In : European Journal of Medicinal Chemistry. 146, p. 354-367 14 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Mifepristone
Derivatives
Pharmacokinetics
Structural optimization
3 Citations

Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation

Liu, Z., Tian, B., Chen, H., Wang, P., Brasier, A. R. & Zhou, J., May 10 2018, In : European Journal of Medicinal Chemistry. 151, p. 450-461 12 p.

Research output: Contribution to journalArticle

Inflammation
Drug Design
Genes
Interleukin-8
Lysine
3 Citations

Erythrosin B is a potent and broad-spectrum orthosteric inhibitor of the flavivirus NS2B-NS3 protease

Li, Z., Sakamuru, S., Huang, R., Brecher, M., Koetzner, C. A., Zhang, J., Chen, H., Qin, C. F., Zhang, Q. Y., Zhou, J., Kramer, L. D., Xia, M. & Li, H., Feb 1 2018, In : Antiviral Research. 150, p. 217-225 9 p.

Research output: Contribution to journalArticle

Erythrosine
Flavivirus
Peptide Hydrolases
Yellow fever virus
Food Additives