Harikanth Venkannagari

  • 204 Citations
  • 8 h-Index
20122018
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  • 4 Similar Profiles
Tankyrases Medicine & Life Sciences
ADP Ribose Transferases Medicine & Life Sciences
Adenosine Diphosphate Ribose Medicine & Life Sciences
Poly(ADP-ribose) Polymerases Medicine & Life Sciences
Enzyme Inhibitors Chemical Compounds
Adenosine Diphosphate Chemical Compounds
Scaffolds Chemical Compounds
Adenosine Chemical Compounds

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Research Output 2012 2018

  • 204 Citations
  • 8 h-Index
  • 12 Article

4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10

Murthy, S., Desantis, J., Verheugd, P., Maksimainen, M. M., Venkannagari, H., Massari, S., Ashok, Y., Obaji, E., Nkizinkinko, Y., Lüscher, B., Tabarrini, O. & Lehtiö, L., Aug 5 2018, In : European Journal of Medicinal Chemistry. 156, p. 93-102 10 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins
Benzamides
ADP Ribose Transferases
Poly(ADP-ribose) Polymerases
Enzyme Inhibitors

Adenosine analogs bearing phosphate isosteres as human MDO1 ligands

Zhang, Y., Jumppanen, M., Maksimainen, M. M., Auno, S., Awol, Z., Ghemtio, L., Venkannagari, H., Lehtiö, L., Yli-Kauhaluoma, J., Xhaard, H. & Boije af Gennäs, G., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Bearings (structural)
N-Glycosyl Hydrolases
Adenosine Diphosphate Ribose
ADP-ribosylarginine hydrolase
Enzyme Inhibitors
7 Citations

Development and structural analysis of adenosine site binding tankyrase inhibitors

Haikarainen, T., Waaler, J., Ignatev, A., Nkizinkiko, Y., Venkannagari, H., Obaji, E., Krauss, S. & Lehtiö, L., Jan 15 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 2, p. 328-333 6 p.

Research output: Contribution to journalArticle

Tankyrases
Structural analysis
Adenosine
Binding Sites
Scaffolds
3 Citations

Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei

Schlesinger, M., Vilchez Larrea, S. C., Haikarainen, T., Narwal, M., Venkannagari, H., Flawiá, M. M., Lehtiö, L. & Fernández Villamil, S. H., Mar 23 2016, In : Parasites and Vectors. 9, 1, 1461.

Research output: Contribution to journalArticle

Adenosine Diphosphate Ribose
Poly Adenosine Diphosphate Ribose
Trypanosoma brucei brucei
Poly(ADP-ribose) Polymerases
Hydrogen Peroxide
8 Citations

Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage

Venkannagari, H., Verheugd, P., Koivunen, J., Haikarainen, T., Obaji, E., Ashok, Y., Narwal, M., Pihlajaniemi, T., Lüscher, B. & Lehtiö, L., Oct 20 2016, In : Cell Chemical Biology. 23, 10, p. 1251-1260 10 p.

Research output: Contribution to journalArticle

ADP Ribose Transferases
Adenosine Diphosphate
DNA Damage
Cells
Apoptosis